Chemical treatment transforms skin cells into neurons

first_img Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe Sign up for our daily newsletter Get more great content like this delivered right to you! Country Click to view the privacy policy. Required fields are indicated by an asterisk (*) Emailcenter_img Two teams of researchers have found different ways to perform the same biological identity swap: turning skin cells into neurons. Both approaches, which involve merely adding a few chemicals to cells, could lead to new ways to treat a person’s disease using cells from their own body. Most of the ways scientists turn one type of cell into another, or into more basic stem cells, depend on adding genes to the original cells. But this gene insertion approach has drawbacks. Its intricate steps are time-consuming, and there’s always a chance the added gene could land somewhere on a chromosome that activates a cancer-causing gene.The new approaches—both published online today in Cell Stem Cell—take a less invasive route. The key, explains Gang Pei, a biochemist at the Shanghai Institutes for Biological Sciences in China, and a co-author on one of the studies, are so-called small molecule chemicals that can slip into a cell, enter the DNA-containing nucleus, and alter the activity of a gene. Pei and his team probed thousands of chemicals to identify those that could convert one cell type into another and found a specific recipe of molecules that essentially switched off skin cell genes in human cells and turned on neuron genes. When the group added seven small molecules denoted as VCRFSGY (valproic acid, CHIR99021, Repsox, Forskolin, SP600125, GO6983, and Y-27632), to a petri dish of human skin cells, the cells transformed into mature, functional neurons over the course of a few weeks. VCRFSGY works in stages. The initial four chemicals, VCRF, start by changing physical traits, acting on a gene called Tuj1, which is specifically active in neurons. But VCRF alone leaves the cell in an unhappy medium: not a true skin cell and not yet a neuron either. The rest of the chemicals—SGY—round out the conversion by amplifying the neuronal development initiated by VCRF. Not only did the resulting cells look like neurons, they acted like them, too: They were able to fire action potentials, a key component that underlies the basics of neuron communication, the team reports.In the second study, another group of researchers based in China accomplished the same task in mouse cells, using a different chemical cocktail. The fact that two different chemical combinations are able to transform skin cells into neurons suggests that this technique can compete with gene insertions for cellular reprogramming, says HongKui Deng, co-author on the mouse cell study and cell biologist at Peking University in Beijing.Molecular and cell biologists say the technique could become an important player in personalized medicine, specifically in using a patient’s own cells to develop therapies for their disease or even to provide a source of transplantable cells for treatment. Indeed, Pei’s team showed that skin cells from an Alzheimer’s patient could be coaxed into neurons that expressed several telltale markers of Alzheimer’s disease. These results lay the groundwork for future Alzheimer’s research, giving scientists a safe and accurate platform to test the effects of possible new drugs, Pei says.These cell-transforming collections of small molecules could really help transform medicine as well, says Jenny Hsieh, a molecular biologist at the University of Texas Southwestern Medical Center in Dallas, who was not involved with either study. “We’re just scratching the surface here.”last_img

Leave a Reply

Your email address will not be published. Required fields are marked *