Share this storyLoblaw profit beats expectations as more people shop at its food and drug stores Tumblr Pinterest Google+ LinkedIn Comment Sponsored By: Facebook Recommended For YouOman urges Iran to release seized tankerDavid Rosenberg: Deflation is still the No. 1 threat to global economic stability — and central banks know itTrans Mountain construction work can go ahead as National Energy Board re-validates permitsBank of Canada drops mortgage stress test rate for first time since 2016The storm is coming and investors need a financial ark to see them through Loblaw Cos Ltd said retail same-store sales, both in the food and drug segments, grew 1.7 per cent in the quarter.Canadian Press Reddit Twitter Loblaw profit beats expectations as more people shop at its food and drug stores Canada’s largest grocer expands home delivery to compete with Amazon.com Reuters February 21, 20197:24 AM EST Filed under News Retail & Marketing advertisement Loblaw Cos Ltd reported a better-than-expected quarterly profit on Thursday, as more people shopped at the Canadian retailer’s food and drug stores.In the face of stiff competition from Amazon.com Inc , Loblaw has been expanding its home delivery services in Canada, through its partnership with San Francisco-based online grocery chain, Instacart.Adjusted gross profit in the retail segment, the company’s biggest, rose 2.6 per cent to $3.25 billion.The company said retail same-store sales, both in the food and drug segments, grew 1.7 per cent in the quarter.Excluding items, the company earned $1.07 per share, beating analysts’ average estimate of $1.04 per share, according to IBES data from Refinitiv.Net profit available to shareholders rose to $221 million, or 59 cents per share, in the fourth quarter ended Dec.31, from $31 million, or 8 cents per share, a year earlier.Revenue rose to $11.22 billion from $10.99 billion.© Thomson Reuters 2019 Featured Stories More Email What you need to know about passing the family cottage to the next generation Join the conversation → 0 Comments ← Previous Next →
Home Depot offers an eight-pack of EcoSmart 60W A19 LED Light Bulbs for $13.97 shipped. Regularly up to $20, today’s deal is $1 less than our previous mention. Working out to roughly $1.75 per bulb, this is a solid price on LED light bulbs. Rated 4.9/5 stars. more… Source: Charge Forward
According to Polestar, this is far from the first building to shout from the rooftops about the company’s conservative Swedish design credentials. The company has also used major luxury events like the Goodwood Festival of Speed, the Geneva Motor Show, and the Pebble Beach Concours d’Elegance as venues to express its sense of style.The Polestar Cube was designed by Swedish architecture firm Bornstein Lyckefors, with plenty of input from the Polestar team. The outfit’s new digs come ahead of its first dedicated factory, in Chengdu, China, and just one year after its introduction in Shanghai. Polestar 1 Makes North American Debut In Pebble Beach Author Liberty Access TechnologiesPosted on October 22, 2018Categories Electric Vehicle News Source: Electric Vehicle News Called (imaginatively) the Polestar Cube, the building may share its shape with the ships of Captain Picard’s arch-nemesis, but it’s anything but terrifying. The white glass façade looks like something Apple would build (if it didn’t have a flying saucer for its headquarters) and is but one part of a new complex in Gothenburg dedicated to Volvo’s new all-electric sub-brand. Aside from the windows, the only break in the smooth surface is for Polestar’s star-shaped logo, which is lit up in white.“Minimalistic, avant-garde design is at the core of the Polestar brand, in our cars and in the way that we interact with our customers. Design also plays a role in how we feel and cooperate in our workplace,” Thomas Ingenlath, Volvo’s design boss, said in a release. “With the new headquarters, we wanted to transform an existing structure to create a new, modern building on the Volvo Cars campus that expresses our brand values, and which becomes an inspiring and desirable place for our global team to work.” More Polestar News Polestar Will Change How Customers Buy Cars In U.S. Assimilate this.Of the many big baddies from the Star Trek universe, the Swedish-sounding Borg rank as one of the most terrifying, with their faceless cube-shaped ships destroying anything and everything in their path. This cube in Sweden is not a destroyer of worlds, though. It’s just the new home of Polestar. Polestar 1 Prototypes Enter Production
The newest version of the Model 3 is now in production.First VINs (Vehicle Identification Numbers) have started to come in for the Model 3 Mid Range aka Model 3 MR. VINs are assigned to cars after the car enters production. First deliveries are expected next week. The Model 3 Mid Range was nicknamed ‘Lemur’ after Elon’s tweet a couple of weeks ago when he unexpectedly announced this new trim level in a cryptic way.More Model 3 Mid Range Info In-Depth Look At Tesla Model 3 Mid-Range Electric Miles The screenshot is from the Teslike Model 3 Order Tracker. You can use the Google form here to add your data if you have configured a Model 3.Based on my latest calculation, I estimate that the Model 3 MR battery pack has 3,648 cells compared to 4,416 for LR and 2,976 for SR. Tesla seems to slightly under-advertise Model 3 battery capacities.In terms of gross margins, after the latest price adjustments, the Model 3 MR has only 1.5% worse gross margins than the LR. Here are the details of my calculation:If the 3,648 cell count estimate is accurate, the range of the Model 3 MR with the 18″ wheels and aero covers is expected to be more than the 2014 Model S 85 and 2018 Model S 75D and same as the 2016 Model S 90D. Interestingly, it is also more than the Model 3 LR AWD with 19″ wheels or the Model 3 Performance with 20″ wheels.Source: Teslike.com Source: Tesla Model 3 Mid-Range Battery Pack Is 62 kWh Author Liberty Access TechnologiesPosted on October 30, 2018Categories Electric Vehicle News Tesla Increases Price Of New Mid-Range Model 3 Source: Electric Vehicle News
Pininfarina Battista Featured By Fully Charged: Video In Horsepower War, Rimac C_Two Proves Electric Cars Can’t Be Matched The all-electric hypercar will arrive next year.Prominent high-end car dealer H.R. Owen will be the exclusive retail partner for Pininfarina in the UK.The company, which sells Ferrari and Rolls-Royce products in the UK, as well as those from other brands, will sell and service the Italian firm’s Battista all-electric supercar from its London headquarters when it arrives next year.“We are delighted to add Automobili Pininfarina to the H.R. Owen portfolio of the world’s leading premium sports and luxury automotive brands,” said H.R. Owen CEO Ken Choo. “The Pininfarina Battista is the hypercar of the future, featuring world-beating performance and innovative EV technology in a beautiful form.More Battista News “Our hugely experienced and talented team look forward to ensuring an ownership experience as revolutionary as Battista itself,” Choo added. “The addition of Pininfarina further reinforces the vision of our owner and Berjaya Group founder, Vincent Tan, in placing H.R. Owen at the forefront of the electric revolution underway in the hypercar segment.”The Pininfarina Battista is the most powerful road car to ever come out of Italy, eclipsing all efforts from more established car ‘makers’ like Ferrari, Lamborghini, and Pagani. Rene Wollmann, who led the development team for the Mercedes-AMG One hypercar, worked on the Battista in his new role as programme director, sportscars for Automobili Pininfarina.A Rimac-supplied 120 kWh battery pack helps deliver 874 bhp and 1,694 lb-ft of torque, which is enough to rocket it from 0-60 in less than two seconds, to 186 mph in under 12 seconds, and onto a top speed of 218 mph.Just 150 Battistas will be made, each with a starting price of just under £2 million. It made its UK debut last weekend at the 77th Member’s Meeting at Goodwood. H.R Owen representatives attended the event to meet prospective customers. Author Liberty Access TechnologiesPosted on April 13, 2019Categories Electric Vehicle News Source: Electric Vehicle News Pininfarina Batista Shows Up With 1,900 HP In London
Renault Kangoo Z.E. Concept foreshadows the renewal of the Kangoo Z.E., scheduled for 2020Source: Electric Vehicle News
Source: Charge Forward Fisker doesn’t plan on fully revealing a “drivable prototype” of its electric SUV until this December, but company chairman and CEO Henrik Fisker has been releasing a number of teaser images of the EV on Twitter in recent days. more…Subscribe to Electrek on YouTube for exclusive videos and subscribe to the podcast.https://www.youtube.com/watch?v=V1zk7Eb8r-s&list=PL_Qf0A10763mA7Byw9ncZqxjke6Gjz0MtThe post Far from production, Fisker continues to tease features for its electric SUV, including a solar roof appeared first on Electrek.
How much do you know about the Foreign Corrupt Practices Act? Let’s find out in this week’s FCPA challenge.Elevate your FCPA knowledge and practical skills at the FCPA Institute – Seattle (August 13-14). To learn more and register click here. FCPA Professor has been described as “the Wall Street Journal concerning all things FCPA-related,” and “the most authoritative source for those seeking to understand and apply the FCPA.”Set forth below are the topics discussed this week on FCPA Professor.This post highlights what you need to know from the second quarter regarding FCPA enforcement and related developments and this post represents a mid-year FCPA report.There were plenty of fireworks across the FCPA landscape this week. As highlighted here, Beam became the latest alcoholic beverage company to resolve an enforcement action concerning conduct in India by pouring $8.2 million into the Treasury. As highlighted here, Credit Suisse became the latest financial services company to resolve an enforcement action concerning internship and hiring practices by paying approximately $77 million.This post rounds up other FCPA or related developments.
« Brexit Explained There is no question that Britain has witnessed its economy decline every since joining the Eu back in 1973. The coup against Margaret Thatcher and the desire to even surrender the pound was only halted by the free markets during the ERM Crisis of 1992-1993. Had it not been for that crisis which actually made George Soros famous, the British pound would no longer exist for they would have been in the Eurozone.Ironically, it has been Soros who has been opposing BREXIT and trying to fund the remain segment and advocates the surrender of the pound. The Telegraph reported that Soros “is one of three senior figures linked to the Remain-supporting campaign group Best for Britain who plan to launch a nationwide advertising campaign this month, which they hope will lead to a second referendum to keep Britain in the EU.” Soros has been backing the idea of one-world government in the EU.The 224-Year Cycle of Political Change warns that by 2036, we may no longer see the Conservative Party. Theresa May never wanted to leave the EU – she was personally against it. All of the trade data proved beyond a shadow of a doubt that there was no tremendous advantage to being in the EU.What has been very clear is that Teresa May has really undermined the Conservative Party with its support falling below 10% in the EU elections. May’s defeat has been brought about by Brussels’ refusal to negotiate and thus May and just accepted that position and constantly tried to get Britain to surrender its sovereignty in the process. The Conservatives are on course for their lowest ever share of the vote in a nationwide ballot and many fear that they could even slip into fifth place behind the Greens. Remember one thing. Like plays and fashion which begin in London and then migrate to the USA, the same is true of politics. This is a warning to American political parties. Trump was elected NOT as a fluke, but as a vote against the establishment. We are witnessing the very same trend in Britain. The term “Conservative” was suggested as a title for the party by a magazine article by J. Wilson Croker in the Quarterly Review in 1830. The name immediately caught on and was officially adopted under the aegis of Sir Robert Peel around 1834. However, it really began to take shape in 1812 when the name “Tory” was commonly used for a new party according to historian Robert Blake. Blake stated that Pitt’s successors after 1812 “were not in any sense standard-bearer’s of true Toryism”. Nevertheless, it was 1834 when the name “Conservative Party” was adopted and it replaced Tory as the dominant name by 1845. Why is BREXIT Important to USA? » Categories: BRITAIN, Politics
12th District Senator Brad Hawkins announced a listening tour throughout the district. The tour begins September 11th in Leavenworth and will hit Wenatchee, Chelan, Waterville Twisp and other locations before wrapping up with a community hike at Patterson Mountain near Winthrop on Friday the 14th. Hawkins says the listening tour provides an opportunity for constituents or stakeholder groups to meet with the Senator by separate appointments. To schedule an appointment with Hawkins, contact his office by sending an e-mail to email@example.com or phone his legislative office in Olympia at 360-786-7622.
by, Kavan Peterson, Editor, ChangingAging.orgTweetShareShareEmail0 SharesLast Friday, Dr. Bill Thomas put out an urgent request to the ChangingAging community to help save the Kickstarter fundraising campaign for the documentary film “Alive Inside: A Story of Music & Memory.” The campaign was in danger of losing all its pledged funding if it didn’t raise an additional $3,000 by Monday to meet the $50,000 Kickstarter goal.We spread the word on the blog and Facebook and Twitter. Bill told me that if the goal wasn’t met by Monday, we would do a rare email blast to our fans. Instead, just a few hours later, we got the word from director Michael Rossato-Bennett that the donations poured in and they had exceeded their goal.We’re thrilled that “Alive Inside” met it’s goal and will be able to finish production of the groundbreaking film. If you happen to be attending The Pioneer Network Annual Meeting in Jacksonville, Florida, next week, I have more cool news — “Alive Inside” will be screened at the conference in an exclusive preview for the culture change world. Check it out.You can find Alive Inside on Facebook at www.facebook.com/bealiveinside, and on Twitter @AliveInsideFilm. Related PostsFinal Push Needed For ‘Alive Inside’As many readers know, I’ve had the pleasure of working with documentary film director Michael Rossato-Bennett on a groundbreaking documentary film ‘Alive Inside’: A Story of Music & Memory. ‘Alive Inside’ is the story of Dan Cohen, a small town social worker who discovers how personalized music can “awaken” and regenerate deeply locked…Music Can Be at the Heart of a Life Worth Living: Dr. Bill Thomas in Alive InsideMillions of people watched the YouTube video of Henry, a nursing home resident, literally “come alive inside” after listening to some of his favorite music. The most recent web clip from the documentary Alive Inside features Dr. Bill Thomas on how music can be at the heart of a life…Innovators Take To the Road to Disrupt DementiaMichael Rossato-Bennett, director of the award-winning documentary, Alive Inside, is teaming up with Dr. Bill Thomas’ Age of Disruption Tour to create a first-of-its kind workshop to Disrupt Dementia.TweetShareShareEmail0 SharesTags: alive inside Dementia music
May 30 2018After a decade of work, a team led by Hôpital Maisonneuve-Rosemont researcher and Université de Montréal associate professor Dr. Gilbert Bernier has shed promising light on the origin of the most common and prevalent form of Alzheimer’s disease, hoping to someday help mitigate or even reverse the progress of the disease. The team’s results are published in the prestigious scientific journal Cell Reports.One person in two over the age of 90 will suffer from Alzheimer’s disease (AD) to some degree. As the population ages, AD and its related conditions are becoming a veritable epidemic, with seemingly no cure in sight. Genetic in a small proportion of people (those with early-onset AD), the disease’s origin is unknown in 95 per cent of cases; age is the principal risk factor. Many researchers are trying to better understand the genetic and pathophysiological risk factors of AD, but few studies have focused on the origin of Alzheimer’s disease and its relationship with aging of the brain.Working from the premise that the causes of the most prevalent form of AD are not genetic but instead epigenetic (i.e. there is a change in gene function), Dr. Bernier and his team carried out an extensive scientific investigation to better understand the role of a specific gene, BMI1, in the onset and development of the disease.Following the BMI1 gene, step by stepIn a study published in 2009, researchers found that, in mice, the mutation of the BMI1 gene triggered an accelerated and pathological aging of the brain and eyes. Based on this finding, Dr. Bernier’s team deduced that if the BMI1 gene stopped functioning in a human, it would also cause accelerated aging of the brain and the development of conditions related to AD.By comparing the brains of deceased AD patients (taken from samples in the Douglas Bell Canada Brain Bank) with those of deceased non-AD patients of the same age, the team observed a marked decrease of the BMI1 gene only in patients who died of AD. To verify that this decrease was not simply a consequence of the disease, the researchers repeated the process with patients who died of early onset AD, a genetic and much rarer form of the disease that strikes before the age of 50 and sometimes even before 40. The researchers discovered that there was no change in BMI1 gene expression in these cases.Related StoriesNew therapy shows promise in preventing brain damage after traumatic brain injuryRevolutionary gene replacement surgery restores vision in patients with retinal degenerationAn active brain and body associated with reduced risk of dementiaIn a third step, the team examined the brains of individuals who died from other aging-related dementias, and once again observed no change in BMI1 gene expression. Finally, using a complex method, the researchers were able to recreate, in the laboratory, neurons found in Alzheimer’s disease patients and healthy individuals. Once again, BMI1 gene expression only decreased in neurons of Alzheimer’s-disease patients.The team concluded that the loss of BMI1 gene expression in the brains and neurons of patients with the common form of AD was not a consequence of the disease and could therefore be the cause.Reproducing Alzheimer’s disease in the labThe researchers then wanted to test their hypothesis that the loss of BMI1 plays a direct role in the development of AD. To do so, they created healthy human neurons in the lab. Once the neurons reached maturity, they deactivated the BMI1 gene using a genetic method.The results were truly spectacular. All the neuropathological markers of AD were reproduced in the lab. The researchers concluded that the loss of BMI1 function in human neurons was enough to trigger AD.Encouraged by their unexpected findings, the researchers also ran molecular studies to understand how the loss of BMI1 triggers AD. These studies revealed that the loss of BMI1 causes an increase in production of beta-amyloid and tau proteins and a decrease in the neurons’ natural capacity to eliminate toxic proteins.Hope for the futureEncouraged by their results, the researchers have good reason to believe that the restoration of BMI1 gene expression in the neurons of Alzheimer’s disease patients in the early stages could mitigate or even reverse the progress of the disease.In 2016, researchers established a company (StemAxonTM) that aims to develop a drug to treat Alzheimer’s disease.Source: http://nouvelles.umontreal.ca/en/article/2018/05/29/understanding-the-origin-of-alzheimer-s-looking-for-a-cure/
Jun 7 2018A class of immunotherapy drugs called checkpoint inhibitors has shown great promise against cancer in some patients. However, researchers’ attempts to boost the drugs’ efficacy by combining them with other immunotherapies have been disappointing. An article in Chemical & Engineering News (C&EN), the weekly news magazine of the American Chemical Society, describes the many challenges involved with harnessing the immune system to fight cancer.In 2014, the U.S. Food and Drug Administration (FDA) approved two different PD-1 inhibitors, a type of checkpoint inhibitor that works remarkably well at shrinking certain types of tumors. Researchers wondered if those drugs – Merck & Co.’s Keytruda and Bristol-Myers Squibb’s Opdivo – might work for more people with cancer if combined with another type of immunotherapy called IDO1 inhibitors. A slew of trials was launched to test the theory. But after the failure of a large study pairing Keytruda with Incyte’s IDO1 inhibitor epacadostat, some are questioning the rush into studies combining immunotherapies, writes Senior Correspondent Lisa M. Jarvis.Competition among drug companies has accelerated some immunotherapies through basic research and early-stage clinical trials before scientists fully understand how they work. As a result, combined immunotherapies that hint at benefits in animal models and early-phase clinical trials often don’t pan out in Phase III trials – the large, expensive studies that are the final step before FDA approval. To increase the chances of bringing a successful combined immunotherapy to market, some experts say that well-planned, randomized mid-stage trials should be conducted before jumping the gun to large Phase III trials.Source: https://www.acs.org/content/acs/en/pressroom/presspacs/2018/acs-presspac-june-6-2018/are-two-cancer-immunotherapy-drugs-better-than-one.html
Jun 18 2018Physical activity plays an important part in dementia prevention. In order to identify risk factors for this neurological disease more effectively, scientists will increasingly focus on big data and genetic research, experts reported at the Congress of the European Academy of Neurology in Lisbon.The question of whether physical activity can prevent dementia and if so, how, is a research question of particular interest. “Today we know that being in good physical condition also ensures a healthy brain. In addition, observational studies suggest that individuals who are physically active also have a better cognitive status,” Prof Ana Isabel Verdelho (Lisbon) told the 4th Congress of the European Academy of Neurology (EAN) in Lisbon.The neurologist is conducting a study that is investigating whether physical activity can actually prevent cognitive damage caused by circulatory disorders of the brain. “The search for suitable study participants is proving difficult. If individuals who have been physically active throughout their life do not develop dementia, you cannot necessarily conclude that physical activity is the reason. These persons may have taken other good decisions as well, for example, a healthy diet or regular checks for vascular risk factors.” The study that now is going on compares subjects that all have in common signs of a vascular disease of the brain. Participants are randomized in two groups, one with supervised physical activity, and the other without supervised physical activity. The aim is to ascertain if physical activity is specifically associated with better cognitive outcomes.Risk factors for dementiaThe most important risk factors for dementia are well known. Prof Verdelho: “Risk factor number one is age – the older a person is, the greater the probability of he or she suffering from dementia.” A second risk factor has to do with formal education. Dr Verdelho explained: “If people are mentally active their whole life, dementia starts later on. One of the reasons might be that deficits do not occur until late in a very active brain.”Vascular factors such as high blood pressure, diabetes, obesity, and cholesterol are also crucial. “The impact of these negative factors is especially important if they already present at a young age. Most people do not undergo examinations in their 30s or 40s to see if they have high blood pressure. But for the sake of dementia prevention, we should start with preventive examinations earlier.” Nutrition is also known to play a key role. Prof Verdelho: “As in many other health areas, a Mediterranean diet – i.e. diet with a lot of fish, vegetables and olive oil – proved to promote dementia prevention.”Big data supports dementia research One problem faced in dementia research is that symptoms of the disease remain invisible until they noticeably impair the person involved. Prof Verdelho: “It is therefore difficult to find patients for randomized studies on dementia prevention.” In addition, data obtained from studies only allow conclusions to be drawn on the investigated groups of patients, not on the general population. Researchers hope for advances from what they call the big data approach. It involves recording and analyzing ever greater quantities of data in ever shorter periods of time. The possibilities opened up by big data are promising. Prof Verdelho: “With these possibilities, we could improve our models for the course of dementia as well as better understand the risk factors and causes of the disease and diagnose them earlier. Moreover, resource distribution could be optimized and tailored treatments could be made available to patients exhibiting special courses of the disease.” All this could happen, in particular, if we include data from electronic health records, data about molecular biomarkers, and data from mHealth, i.e. data from mobile electronic devices such as smart phones. However, big data raises a number of technical and scientific issues as well as questions regarding data protection law. Prof Verdelho: “Larger sets of data are not necessarily better sets of data. Precision and critical analysis will be the keys for making optimum use of this data. Although we assume that big data is one of the correct paths to new findings, this approach has not yet arrived at a point where it affects actual practices of prevention or treatment.”Related StoriesCommon medications can masquerade as dementia in seniorsAn active brain and body associated with reduced risk of dementiaCaregiver depression linked to increased emergency department visits for patients with dementiaThe search for dementia genesAnother relatively new approach in dementia research involves genetics or genetic diagnosis. “We will benefit greatly from it in the future. But this approach has not yet brought about any effective therapy for curing dementia or slowing down its progress,” Prof Verdelho noted. The variations of three genes – UNC5c, ENC1 and TMEM106B – are known to increase the ability to resist pathological changes of the kind that occur with Alzheimer’s, strokes and other neuropathologies. TMEM106B is likewise known as a protective gene with respect to the development of frontotemporal types of dementia. Alzheimer’s disease accounts for 50 to 75 percent of dementia cases. The genes associated with its etiology (APP, PSEN1, PSEN2) were discovered 30 years ago. “However, these Alzheimer genes also have mutations whose pathogenicity is unknown. And there is still no test on how to make a distinction between the gene variant that allows Alzheimer’s to occur and the neutral variants,” Prof. Verdelho noted and then summarized as follows: “The ability of the brain to resist pathological changes could depend to a crucial extent on the underlying genetic base. We could develop new therapies against dementia from further findings on the protective mechanism of these genes.”Dementia is a disease with a series of symptoms such as loss of memory, cognitive impairment and behavioral changes that greatly impair daily life. 47 million people worldwide suffer from dementia. By 2050 there will be 131 million. Dementia therefore represents a major social and economic burden. Source:https://www.ean.org/
Aug 21 2018Tooth loss is a significant health issue currently affecting millions of people worldwide. While artificial dental implants are the existing standard tooth replacement therapy, they do not exhibit many properties of natural teeth and can be associated with complications leading to implant failure. Two articles published in the September 2018 issue of the Journal of Dental Research share recent advances in bioengineering teeth.In the article “Bioengineered Tooth Buds Exhibit Features of Natural Tooth Buds” Pamela Yelick, Tufts University School of Dental Medicine, Boston, Mass., USA and co-authors explored new methods to create highly cellularized bioengineered tooth bud constructs that include features that resemble natural tooth buds such as the dental epithelial stem cell niche, enamel knot signaling centers, transient amplifying cells and mineralized dental tissue formation. The constructs were composed of postnatal dental cells encapsulated within a hydrogel material that were implanted subcutaneously into immunocompromised rats.Related StoriesTransobturator sling surgery shows promise for stress urinary incontinenceBordeaux University Hospital uses 3D printing to improve kidney tumor removal surgeryIt is okay for women with lupus to get pregnant with proper care, says new studyThis is the first report that describes the use of postnatal dental cells to create bioengineered tooth buds that exhibit evidence of these features of natural tooth development, pointing to future bioengineered tooth buds as a promising, clinically relevant tooth replacement therapy.In the article “Bone Marrow Stromal Cells Promote Innervation of Bioengineered Teeth” Sabine Kuchler-Bopp, French National Institute of Health and Medical Research and Fédération de Médecine Translationnelle de Strasbourg, France, and co-authors developed a strategy where autologous mesenchymal cells coming from bone marrow can be used to supply nerves to bioengineered teeth without treatment that uses an immunosuppressor. The innervation of teeth is essential for their function and protection but does not occur spontaneously after injury. This new method provides innervation while avoiding multiple side effects associated with immunosuppressors.”These exciting studies point to a promising future for bioengineered teeth,” said Journal of Dental Research Editor-in-Chief William V. Giannobile. “This cutting-edge research has the potential to advance tooth replacement therapy and the science base to bring such regenerative medicine treatments to improve clinical care.”Source: https://www.iadr.org/IADR/About-Us/News/ArtMID/132983/ArticleID/554/Bioengineered-Tooth-Replacement-Opens-Doors-to-New-Therapies
Image Credit: Image Point Fr / Shutterstock By Dr. Ananya Mandal, MDSep 12 2018According to the Centers for Disease Control and Prevention (CDC), there have been 16 weeks of non-stop flu season last year leading to 700,000 hospitalizations due to influenza as well as pneumonias that occurred as complications.The CDC thus recommends to the general public to get their flu shots well before the flu season begins this year. Ideally all should get their vaccines by the end of October, the federal health officials state.The CDC reports that last year’s flu season was particularly among one of the worst ones. There were hundreds of thousands of hospitalizations and around 180 children died from flu. According to the CDC the flu shots or vaccines are not 100 percent protective against the infection but can provide some measure of protection against this illness. Nearly 80 percent of the children who died of flu last year for example, were not vaccinated against flu.The CDC website statement reads, “Influenza is a potentially serious disease that can lead to hospitalization and sometimes even death.” It adds that millions are affected with this infection that kills thousands every year.The CDC warns that the flu season lasts from October to as late as May the next year with December to February being the peak flu season. This year the CDC officials urge people to start getting their flu shots early before the transmission risk begins. Influenza virus is notorious for its ability to change. This renders the yearly vaccine ineffective against it. Every year the Food and Drug Administration (FDA) has to choose the strain of the flu virus that would be put into the flu shot. This comes from recommendations from the World Health Organization. Around three or four types of influenza viral strains are targeted with the vaccine. This season’s flu vaccine is already being sold at the drug stores in the recent weeks. This new flu shot targets flu strains of the influenza virus.Related StoriesResearchers identify gene mutations linked to leukemia in children with Down’s syndromeWomen’s greater immune response to flu vaccine declines with ageScripps CHAVD wins $129 million NIH grant to advance new HIV vaccine approachAccording to the CDC recommendations seniors or the elderly are to be given high doses of the vaccine. Other groups that must be vaccinated include pregnant women, people with underlying illnesses and children.CDC states that all babies over the age of six months need to get vaccinated with a traditional flu shot or a nasal spray called FluMist (for children over two years age). This year the spray form of the vaccine is made available again after two years. For the last couple of years this spray mist was not recommended by the CDC’s Advisory Committee on Immunization Practices because of its lack of efficacy against the circulating strains of the virus.According to recommendations from the American Academy of Pediatrics all eligible children should receive the flu shot and the spray mist is to be used only for children who refuse the shots or for paediatricians who have run out of the flu shots. The AAP states that the FluMist is not effective against H1N1 flu strain and is less effective against H3N2 influenza virus.To change this makers AstraZeneca have reformulated the H1N1 portion of the FluMist to improve its efficacy. Dr. Wendy Sue Swanson, a spokeswoman for the AAP and a pediatrician at Seattle Children’s Hospital, says that the organization is still not taking chances and all children must still get the shots with spray kept in reserve for special cases only. “It’s not dangerous per se or ineffective, we just don’t have the experience and confidence for the nasal spray to protect against one of the most commonly circulated strains,” she said.
They call him “Hellboy,” and it’s easy to see why. Had you been there when it lived 68 million years ago in what is now Alberta province, Canada, you would not have wanted to mess with this horned dino, a close relative of the famed Triceratops. In addition to the sharp horns on its nose and over its eyes, which were probably used for defense against predators like Tyrannosaurus rex, this new species—dubbed Regaliceratops peterhewsi—had a particularly ornate frill behind its head, most likely for sexual display. (Regaliceratops in Latin means “royal horned face,” and peterhewsi is in honor of local geologist Peter Hews, who discovered it.) The researchers, who describe the creature online this week in Current Biology, are particularly excited, because although he is definitely a cousin of Triceratops, his horns and frill more closely resemble those of another group of horned dinos that includes Centrosaurus and which were already extinct when Hellboy came along. That means the new dino’s ornamentation is a case of independent evolutionary invention (also known as convergent evolution), the authors say. The paper includes another example of what might be called sexual display: At its very end, the lead author asks a fellow researcher at the museum to marry him. (After seeing a preprint, she has already said yes.)